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Single Particle Analysis Resolves Details of Ligand Binding Sites and Interactions
Obtain functional insights into your macromolecules and biologics by visualizing your target’s structural components and binding sites to accelerate drug design and development.
With cryo-EM, structural biologists can easily answer questions regarding the interactions of the small molecules with the chosen target and suggest ways to help design and optimize drug candidates, supporting a structure-based drug design approach.
Overcome Obstacles in Structure Determination with Cryo-EM
Cryo-EM can overcome the challenges of traditional methods like x-ray crystallography and NMR spectroscopy, providing structural information for samples in near-native states.
XRC is popular, however crystallizing proteins can be difficult and sometimes requires extensive modifications of a protein’s native structure.
NMR spectroscopy can be done in solution on full length proteins, but its use is limited to small, highly homogenous, generally soluble biomolecules.
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